If you have a history of recurrent urinary tract infections (UTIs) and would like to contribute to clinical research, you may be eligible to enroll in Bonafide Health’s urinary health study.

Recurrent UTIs are one of the most common infections, with an estimated 60% of women experiencing at least one during their lifetime. While advances continue to be made in understanding and treating urinary health conditions – and the number of products addressing UTIs continues to grow – many women live with frequent recurrence of symptoms.

While the gold standard UTI treatment – a course of antibiotics – can mitigate UTI symptoms, up to half of all patients will have a recurrence of symptoms within 6 months. Pathogens can also create biofilms along the urinary tract, reducing the impact of antibiotics.

Uqora has released a new dietary drink mix designed to help prevent UTIs by combining D-mannose, cranberry, vitamins, and minerals. Researchers at Uqora and Bonafide Health are looking for women with recurrent UTIs who are interested in joining a clinical study examining the efficacy of the new drink mix, Flush Advanced+. Participation in the study can be completed from home.

You may be eligible to participate if you:

• Are a woman aged 18-75.
• Currently reside in the United States.
• Experience recurrent UTIs* and are otherwise healthy.
• Are not currently pregnant and do not plan to become pregnant in the next 6 months.
• Are willing and able to agree to the requirements of the study.

*Participants must provide proof of 2 or more symptomatic, culture-confirmed UTIs from the 6 months prior to enrollment.

This clinical trial is a double-blind, randomized controlled trial (RCT). If enrolled, you will be randomized into 1 of 2 groups. Half of the participants will receive Flush Advanced+ supplement sachets, and the other half will receive a placebo product, meaning the sachets will contain a substance that looks identical but is inactive. Participants in both groups will be asked to consume one sachet each day for a period of six months. You will not know which product (active or placebo) you are taking during your participation in the study.

Participants in the trial may continue using medications and supplements they usually take for general health, but they may be asked to refrain from taking certain supplements for UTI management during the trial.

If a participant experiences a UTI during the trial, they should take their typical approach to seeking UTI care and/or treatment, including taking antibiotics, if required. Participants will also continue to take the study product drink mix.

After completing the pre-screener form, those who may be eligible for the trial will be invited to attend a virtual visit with a research team member to complete the screening process. The virtual visit will take place via a Microsoft Teams call or a phone call. During the visit, candidates will be asked questions about their demographic information and health history so the research team can confirm whether they are eligible for the study. Candidates will also be asked to provide their urine culture test results from two episodes of UTI within the prior six months. Test results may be shared as a screenshot, photo, or PDF.

Those who are enrolled in the trial may complete their participation at home or another location of their choosing. No in-person visits are required. The study product will be shipped directly to the address they provide. Participants may earn up to $600 for completion of this study.

During the trial, you will be asked to track and report on your urinary health over the course of 6 months, which will include:

• Completing a daily diary to report ‘good’ or ‘bad’ urinary health days (daily time commitment about 5 minutes).
• Completing one or more online questionnaires every two weeks.
• Attending 3 virtual visits with a research team member via a Microsoft Teams call or a phone call. These visits will occur in months 2, 4 and 6.

You won’t have to collect any regular samples! If you experience any UTI recurrence during the study, you will be asked to complete a urine culture test.

Participants in the active product group will receive the Flush Advanced+ sachets free of charge, to be taken daily for the duration of the study.

Participants in both groups may earn up to $600 for completion of this study!

Interested in participating? Click here to fill out the pre-screener.

If you’d like to enroll in the study, you must first meet several criteria. You can fill out the pre-screener form so the research team can assess initial eligibility. Please note that you are NOT required to have an active UTI at the time of entering the study. If you are invited to participate in a virtual screening visit, you will be asked to provide evidence of two culture-confirmed UTI episodes in the prior six months.

If you fill out the pre-screener form and meet initial requirements for the study, you will be sent further information about participation requirements by email. You will be contacted to arrange a screening visit, during which a member of the Bonafide Health clinical team will affirm your eligibility and enroll you into the study.

Completing the pre-screening questionnaire does not represent a commitment to enrolling in the study, and you will have the opportunity to withdraw interest at any time. Participation is completely voluntary.

You can earn up to $600 from participating!

If you have questions about this clinical study, you may contact the Bonafide Health clinical research team at [email protected]